Which of the following transmitter combinations all have at least one ionotropic receptor (i: ligand gated ion channel)?Group of answer choicesGABA, 5-hydroxytryptamine and glutamateAcetylcholine, dopamine and noradrenalineGABA, glutamate and enkephalin5-Hydroxytryptamine, GABA and dopaminenoradrenaline, acetylcholine and GABA
Question
Which of the following transmitter combinations all have at least one ionotropic receptor (i: ligand gated ion channel)?Group of answer choicesGABA, 5-hydroxytryptamine and glutamateAcetylcholine, dopamine and noradrenalineGABA, glutamate and enkephalin5-Hydroxytryptamine, GABA and dopaminenoradrenaline, acetylcholine and GABA
Solution
The correct answer is "GABA, 5-hydroxytryptamine and glutamate".
Here's why:
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GABA: GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory compound in the mature vertebrate central nervous system. There are two classes of GABA receptors: GABA(A) and GABA(B). GABA(A) receptors are ionotropic receptors (ligand-gated ion channels).
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5-hydroxytryptamine (5-HT, or serotonin): Serotonin receptors are found in almost all animals and are known to regulate longevity and behavioral responses. The serotonin 5-HT3 receptor is the only ionotropic receptor in this family.
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Glutamate: Glutamate is the most abundant excitatory neurotransmitter in the vertebrate nervous system. It is a component of a variety of proteins and a key molecule in cellular metabolism. Glutamate receptors are synaptic and non synaptic glutamate-gated ion channels.
The other combinations do not all have at least one ionotropic receptor.
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