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A 62-year-old man comes to the emergency department due to painless vision loss in his left eye.  The patient states that he was watching television when suddenly everything became dark and he could not see out of his left eye.  This resolved spontaneously after approximately 5 minutes and was not associated with headache, slurred speech, numbness, or weakness.  He experienced a similar episode several months ago, at which time he did not seek medical attention.  His medical history is significant for hypertension, type II diabetes mellitus, and hyperlipidemia; he admits that he is not compliant with his medication regimen.  Two years ago, the patient was hospitalized for hyperosmolar hyperglycemic state, and his HbA1c level 4 months ago was 9.5%.  He has a 30-pack-year smoking history.  Temperature is 36.7 C (98 F), blood pressure is 160/90 mm Hg, and pulse is 80/min and regular.  Which of the following is the most likely cause of this patient's symptoms?

Question

A 62-year-old man comes to the emergency department due to painless vision loss in his left eye.  The patient states that he was watching television when suddenly everything became dark and he could not see out of his left eye.  This resolved spontaneously after approximately 5 minutes and was not associated with headache, slurred speech, numbness, or weakness.  He experienced a similar episode several months ago, at which time he did not seek medical attention.  His medical history is significant for hypertension, type II diabetes mellitus, and hyperlipidemia; he admits that he is not compliant with his medication regimen.  Two years ago, the patient was hospitalized for hyperosmolar hyperglycemic state, and his HbA1c level 4 months ago was 9.5%.  He has a 30-pack-year smoking history.  Temperature is 36.7 C (98 F), blood pressure is 160/90 mm Hg, and pulse is 80/min and regular.  Which of the following is the most likely cause of this patient's symptoms?

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Solution

This patient's symptoms of sudden, painless vision loss in one eye that resolved spontaneously are most consistent with amaurosis fugax. Amaurosis fugax is typically caused by a transient ischemic attack (TIA) in the retinal artery, often due to emboli originating from atherosclerotic plaques in the carotid artery. Given the patient's significant risk factors, including hypertension, type II diabetes mellitus, hyperlipidemia, and a history of smoking, he is at high risk for atherosclerosis and subsequent embolic events.

Step-by-step reasoning:

  1. Symptom Analysis: The patient experienced sudden, painless vision loss in one eye that resolved within minutes. This is characteristic of amaurosis fugax.
  2. Risk Factors: The patient has multiple risk factors for atherosclerosis, including:
    • Hypertension
    • Type II diabetes mellitus
    • Hyperlipidemia
    • Smoking history
  3. Medical History: The patient has a history of poor compliance with his medication regimen, which likely exacerbates his risk factors.
  4. Previous Episode: The patient had a similar episode several months ago, suggesting a recurring issue likely related to transient ischemic events.
  5. Vital Signs: Elevated blood pressure (160/90 mm Hg) further supports the presence of uncontrolled hypertension, a significant risk factor for atherosclerosis.

Given these points, the most likely cause of this patient's symptoms is an embolic event from atherosclerotic disease, leading to a transient ischemic attack in the retinal artery.

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