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Question 201 ptsHow is the slow after-hyperpolarisation (sAHP) generated in lamprey spinal neurons?Group of answer choicesit is due to the slow closure of the delayed rectifier channels opened during the downstroke of the action potentialit is mediated by calcium entering the cell which activates a slow calcium-activated potassium currentit is due to opening of sodium-activated calcium pumps in the nerve cell membraneit is due to activation of the Na+/K+ ATPase (sodium/potassium ATPase)it is due to an inhibitory post-synaptic input mediated by glycine Previous

Question

Question 201 ptsHow is the slow after-hyperpolarisation (sAHP) generated in lamprey spinal neurons?Group of answer choicesit is due to the slow closure of the delayed rectifier channels opened during the downstroke of the action potentialit is mediated by calcium entering the cell which activates a slow calcium-activated potassium currentit is due to opening of sodium-activated calcium pumps in the nerve cell membraneit is due to activation of the Na+/K+ ATPase (sodium/potassium ATPase)it is due to an inhibitory post-synaptic input mediated by glycine Previous

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Solution

The slow after-hyperpolarisation (sAHP) in lamprey spinal neurons is generated through the process of calcium entering the cell, which activates a slow calcium-activated potassium current. This process is crucial for the regulation of neuronal excitability and the repolarization of the neuron after an action potential.

Here are the steps:

  1. An action potential, or nerve impulse, is initiated in the neuron. This causes voltage-gated calcium channels to open.

  2. Calcium ions flow into the neuron due to the concentration gradient (there is a higher concentration of calcium ions outside the neuron than inside).

  3. The influx of calcium ions activates a type of potassium channel known as a calcium-activated potassium channel.

  4. The activation of these channels allows potassium ions to flow out of the neuron, again due to the concentration gradient (there is a higher concentration of potassium ions inside the neuron than outside).

  5. The outflow of potassium ions causes the neuron to become more negative, or hyperpolarized. This is the slow after-hyperpolarisation (sAHP).

  6. The sAHP makes the neuron less likely to fire another action potential immediately, effectively providing a refractory period that helps to regulate the rate of nerve impulses.

So, the correct answer to your question is: "it is mediated by calcium entering the cell which activates a slow calcium-activated potassium current".

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