Explain the term mutation?
Solution
A mutation is a change that occurs in our DNA sequence, either due to mistakes when the DNA is copied or as the result of environmental factors such as UV light and cigarette smoke.
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DNA and its role: DNA (deoxyribonucleic acid) is a molecule that carries most of the genetic instructions used in the development, functioning, and reproduction of all known living organisms. It is the carrier of genetic information.
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DNA sequence: The DNA sequence is the particular side-by-side arrangement of bases along the DNA strand (i.e., the arrangement of the nucleotides). This order spells out the exact instructions required to create a particular organism with its own unique traits.
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What is a mutation: A mutation is a change that occurs in this DNA sequence. This can either be a tiny change affecting only one or few nucleotides (base), or a larger change affecting a segment of the DNA.
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Causes of mutation: Mutations can occur due to errors during DNA replication or due to the effects of certain chemicals and radiation. These changes can occur spontaneously at a low rate or can be induced.
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Impact of mutation: Some mutations lead to beneficial variations and are the basis of evolution while others can lead to diseases or disorders (like cancer). Some mutations may not have any noticeable effect.
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Types of mutation: There are several types of mutations, including deletion (a base is lost), insertion (extra base is inserted), substitution (one base is replaced by another), and frameshift (due to insertion or deletion, the reading frame changes).
In summary, a mutation is a change in the DNA sequence within a gene or chromosome of an organism that may alter the product of a gene, leading to a variant form that may be transmitted to subsequent generations.
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