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A 22-year-old man comes to the emergency department because of a 1-day history of fever and nontender skin rash over his trunk. He was diagnosed with Hodgkin lymphoma 1 month ago and recently began combination chemotherapy with doxorubicin, bleomycin, vinblastine, and dacarbazine. Medical history otherwise is unremarkable. His temperature is 39.0°C (102.2°F), pulse is 110/min and regular, respirations are 16/min, and blood pressure is 115/70 mm Hg. Pulse oximetry on room air shows an oxygen saturation of 98%. Cardiopulmonary auscultation discloses clear breath sounds bilaterally and normal heart sounds. The abdomen is soft and nontender; bowel sounds are normal throughout. Multiple nontender, indurated macules and pustules and few gangrenous ulcers are noted over his trunk. Laboratory studies show:Hemoglobin 9.2 g/dLMean corpuscular volume 91 μm3Leukocyte count 2,100/mm3Platelet count 100,000/mm3Serum  Sodium 141 mEq/LPotassium 4.3 mEq/LCreatinine 1.0 mg/dLWhich of the following is the most likely diagnosis?A. Bacillary angiomatosisB. Ecthyma gangrenosumC. Herpes zosterD. Pyoderma gangrenosumE. Stevens-Johnson syndrome

Question

A 22-year-old man comes to the emergency department because of a 1-day history of fever and nontender skin rash over his trunk. He was diagnosed with Hodgkin lymphoma 1 month ago and recently began combination chemotherapy with doxorubicin, bleomycin, vinblastine, and dacarbazine. Medical history otherwise is unremarkable. His temperature is 39.0°C (102.2°F), pulse is 110/min and regular, respirations are 16/min, and blood pressure is 115/70 mm Hg. Pulse oximetry on room air shows an oxygen saturation of 98%. Cardiopulmonary auscultation discloses clear breath sounds bilaterally and normal heart sounds. The abdomen is soft and nontender; bowel sounds are normal throughout. Multiple nontender, indurated macules and pustules and few gangrenous ulcers are noted over his trunk. Laboratory studies show:Hemoglobin 9.2 g/dLMean corpuscular volume 91 μm3Leukocyte count 2,100/mm3Platelet count 100,000/mm3Serum  Sodium 141 mEq/LPotassium 4.3 mEq/LCreatinine 1.0 mg/dLWhich of the following is the most likely diagnosis?A. Bacillary angiomatosisB. Ecthyma gangrenosumC. Herpes zosterD. Pyoderma gangrenosumE. Stevens-Johnson syndrome

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Solution

The most likely diagnosis for this patient is Ecthyma gangrenosum (Option B).

Ecthyma gangrenosum is a rare skin infection commonly caused by Pseudomonas aeruginosa. It is often seen in immunocompromised patients, such as those with neutropenia, which this patient likely has given his low leukocyte count and recent chemotherapy.

The infection typically starts as a painless, red macule that progresses to a pustule and then to a gangrenous ulcer, which is consistent with this patient's presentation. The presence of fever also suggests an ongoing systemic infection.

The other options are less likely given the patient's presentation and history. Bacillary angiomatosis (Option A) is usually seen in patients with HIV. Herpes zoster (Option C) typically presents with painful vesicles in a dermatomal distribution. Pyoderma gangrenosum (Option D) is associated with inflammatory bowel disease, which this patient does not have. Stevens-Johnson syndrome (Option E) typically begins with flu-like symptoms followed by a painful rash and blisters, which this patient also does not have.

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