Amides are most efficiently prepared from which of the following?Select answer from the options belowEstersAcid chloridesCarboxylic acids
Question
Amides are most efficiently prepared from which of the following?Select answer from the options belowEstersAcid chloridesCarboxylic acids
Solution
Amides are most efficiently prepared from Acid Chlorides.
Here's a step-by-step explanation:
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Acid chlorides are highly reactive due to the good leaving group (Cl-).
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When amines (which contain nitrogen) are reacted with acid chlorides, they will attack the carbonyl carbon, causing the double bond oxygen to break and form a single bond.
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The nitrogen will then donate one of its hydrogen atoms to the oxygen, forming a hydroxyl group.
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Finally, the hydroxyl group will be kicked out and replaced by the nitrogen, forming an amide.
So, the most efficient way to prepare amides is from acid chlorides due to their high reactivity.
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