According to the Frank-Starling law of the heart, which of the followingstatements accurately describes the relationship between EDV and strokevolume?A) EDV has no effect on stroke volume.B) As EDV increases, stroke volume decreases.C) There is an inverse relationship between EDV and stroke volume.D) An increase in EDV leads to an increase in stroke volume
Question
According to the Frank-Starling law of the heart, which of the followingstatements accurately describes the relationship between EDV and strokevolume?A) EDV has no effect on stroke volume.B) As EDV increases, stroke volume decreases.C) There is an inverse relationship between EDV and stroke volume.D) An increase in EDV leads to an increase in stroke volume
Solution
D) An increase in EDV leads to an increase in stroke volume.
Explanation: The Frank-Starling law of the heart states that the stroke volume of the heart increases in response to an increase in the volume of blood filling the heart (the end diastolic volume or EDV) when all other factors remain constant. Essentially, the more the heart is filled during diastole (EDV), the more forcefully it contracts and the greater the volume of blood it ejects (stroke volume). This relationship continues until optimal overlap of actin and myosin filaments in cardiac cells is reached. Beyond this point, stroke volume plateaus and can even decrease with further increases in EDV.
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